What should be done to radically prolong life?

Let's start with this:

[Tasks vary in scale]

1. Experimental work to research aging mechanisms. This point, like many others, implies the work of tens, if not hundreds of thousands of researchers.

2. Creating databases. Implementing projects such as First Approval.

3. Summaries, reviews, analytics, selection of promising directions.

4. Training AI for discovering new drugs and targets.

5. Experiments on extending the lifespan of animals.

6. Preclinical studies.

7. Clinical studies.

8. Creating panels and validating aging biomarkers. Clinical studies of the same.

9. Automated lifespan experiment equipment.

10. Scientific organizational work, holding conferences.

11. Writing grant applications, reports.

12. Creating longevity biotech startups.

13. Popular science articles about aging.

14. Creating websites about aging.

15. Books about aging and longevity.

16. Collection and analysis of human health data.

17. Development of recommendation systems.

18. Implementation of personalized medicine standards.

19. Healthy lifestyle organization.

20. Improving the healthcare system.

21. Increasing patient awareness, compliance, access to the best treatment.

22. Creating apps for health monitoring and improvement.

23. Developing gadgets.

24. Miniaturization and enhancement of diagnostic systems. Organizing data flow.

25. Developing new methods of manipulating the living.

26. Everything else about regenerative medicine, organ and tissue replacement.

27. Everything else about the evolutionary-comparative biology of aging. New model animals.

28. Chemoinformatics, quantum chemistry, synthesis of new compounds, quantum chemistry.

29. Creating next-generation antibodies.

30. Creating nanorobots.

31. Human cloning.

32. Promoting futurism, lectures, projects, creating a positive image of the future.

33. Interaction with government agencies, conducting roundtables and consultations.

34. Lobbying research programs.

35. Social media, Reddit, 𝕏.

36. Organizing online forums.

37. Conducting study circles, lectures, journal clubs.

38. University programs in the field of Longevity.

39. Schools, accelerators, workcamps for biotech entrepreneurs.

40. IPO of biotech longevity startups.

41. Developing cryoprotectants.

42. Promoting cryonics by all the above and below-mentioned means.

43. Creating YouTube channels.

44. Creating movies about life extension.

45. Interaction with bloggers, journalists, opinion leaders.

46. Incorporating celebrities in the fight against aging.

47. Exhibitions, creating works of art, art-science.

48. Creating public organizations, patient organizations.

49. Flash mobs, activism, crowdfunding.

50. Open science, crowdsourcing, experimental films.

51. Creation of scientific journals

52. Mechanomedicine, mitochondrial medicine, immune system rejuvenation, genome stability enhancement, lipid metabolism – identifying several vast areas that develop separately from longevity

53. Combating fibrosis, vascular rejuvenation, inflammation research

54. Combatting skin aging

55. Integration of knowledge about aging and pathophysiological processes

56. Research on the relationship between aging and cancer, vaccinations against tumor diseases

57. Microbiome research

58. Creation of living systems as therapeutic and diagnostic agents

59. Development of genetic engineering

60. Development and application of network theory

61. Construction of aging models

62. Head transplantation

63. Brain tissue transplantation

64. Inter-laboratory exchange service for life-extending therapies

65. Political organizations, interaction with politicians, including longevity ideas in election programs

66. Lobbying, drafting legislation

67. Addressing objections through all mentioned means

68. Engaging new players in aging, creating an attractor

69. Creation of longevity territories

70. Network state, crypto longevity

71. Digital immortality: propaganda, creating intellectual avatars, self-description, services, startups. Smart wills

72.Sociological, anthropological, psychological studies of aging, attitudes towards death, and readiness to act

73. Use of network theory in societal analysis and finding the best impact

74. Gamification of the fight against aging

75. Interaction with friendly organizations, cooperation agreements, joint events

76. Propagating transhumanism. Books, films, exhibitions. Philosophical justification of transhumanism

77. Transhumanism discussion with long-termism, effective altruism, and new leftists

78. Merch, clothing, souvenirs, fashion

79. Digital fitness

80. Nutrition research

81. Assessment of the contribution of various molecular mechanisms of aging. Finding the best combination of therapeutic agents against aging

82. Creation of strategies, plans in all areas. Analysis of the situation and possibilities

83. Creation of questionnaires, instructions, rules for those wishing to participate in the Longevity movement. Informatization of the very fight for extending human life

84. Research on the aging and rejuvenation of domestic animals

85. Writing articles, books about non-acceptance of death. Filming

86. Building a Cochrane-like institute for Longevity. Fighting the reproducibility crisis

87. Rechecking key articles in the field of longevity

88. Searching for new forms of organizing science, motivating scientists, and presenting results

89. Formulating exciting scientific and social tasks related to life extension. Organization of awards, contests, competitions. Life extension olympiad

90. Synthesis of material, establishing connections between research, cross-disciplinary projects

91. Large longitudinal studies with extensive data collection

92. Creating something akin to the UK Biobank in all developed countries

93. Creating an atmosphere of moral encouragement for players in the field of Longevity. Alerting the public to the competition in the search for life extension methods

94. Identifying and solving existential risk problems

95. Radiobiology, astrobiology, as ways to find useful solutions in parallel fields

96. Advocacy and lobbying for evidence-based policies. Rational influence on society, application of the scientific method to solve the problem of funding research

97. Formation of radically-minded minorities. Longevity leadership school

98. Collection and presentation of evidence for the realism of the idea of human life extension

99. Special support for bold experiments, original ideas, fundamentally new therapies

100. Creation of currently unknown transhumanist products

All of this is being done, but either insufficiently, blatantly little, or very insignificantly, or only in projects.

Why? I have a definitive answer.

People don't want to live strongly enough.

Even those involved in the industry want to, but not enough. Not enough to go all-in against death.

This and no other problem is what we must solve. The rest will take care of itself without us.

Looking at these, literally, a million projects, we must choose. Just one project. We'll choose a second when we have more resources.

Surprisingly, such a project doesn't lie in the field of aging research. It must be related to the desire to live.

First and foremost, we need to spread the idea: death is extremely bad. The rest will happen automatically.

Proving the badness of death is also a complex activity. But without such projects, we will stagnate.