POD 133: [VIDEO] Dr. Andrew Gallimore on DMTx on a DMT island
Added 2025-10-24 21:09:02 +0000 UTCThis is a great and far-ranging discussion with chemist and neuroscientist Dr. Andrew Gallimore about his continuous DMT infusion project (DMTx) and his new book Death by Astonishment.
Andrew's website:
www.buildingalienworlds.com
Noonautics website:
www.noonautics.org
Eleusis retreat website:
www.eleusismind.com
Comments
My man is asking the tough questions: "Is there a protocol in place for in case you accidently start your own religion?" Very interesting interview all around.
Sherm
2025-12-31 16:36:07 +0000 UTCThis is the best interview I've watched with Andrew Galimore, Hamilton was the perfect guy to interview him, asking all the questions we want answers to, bravo
fractal_gasm
2025-12-19 02:06:28 +0000 UTCHamilton, you need to be running this lab!
Song of the Trees
2025-11-19 12:34:10 +0000 UTCI say keep it up…the homies at MAPS (at least everyone I’ve spoken to) all are def appreciative of you bringing more awareness to the whole psychoposia shit show. I was starting to think the general public would never find out all the details so to me, you’re a fucking hero
Char!
2025-11-14 10:50:05 +0000 UTCAnd iirc for lots of their work (Hoffmeister et al) they used recombinant enzymes instead of messing with the fungi themselves.
Hippo
2025-11-01 19:45:14 +0000 UTCIs this where I can vote to definitely have more Psymposia takedown commentary? I want an entire episode dedicated to it if possible!
Maryam Aziz
2025-11-01 19:07:22 +0000 UTCIIRC some of that work by Gartz was reproduced and verified by GC-MS by a member of the shroomery/DMT-Nexus, but from what I remember it was rather finnicky and particularly substrates with steric bulk were not accepted (so best to try and reproduce with MET/DET at first). I think they said that for substrates with steric bulk (MiPT or even DiPT) it would not work at all really. But this was not with enzyme isolates (which too is quite finnicky from what I heard in the case of those mushrooms and sadly those enzymes are apparently hardly expressed in liquid culture, which would potentially simplify things). Maybe it would be interesting to talk about some of that stuff with Dirk Hoffmeister. PS: About Gartz I heard that in his home city of Leipzig there are surprisingly many patches of lignicolous psilocybe ;) Some to be found are known to cause WLP though.
Hippo
2025-11-01 15:56:26 +0000 UTCIt wasn't Psymposia that called me a psychedelic celebrity, it was Jules Evans, but it's easy to confuse them because they are both anti-psychedelic concern trolls who have received payment from Suzy Sarlo. Evans is just better at pretending to be reasonable.
Hamilton Morris
2025-10-31 18:40:15 +0000 UTCTHIS SHIT FIRE AS HELL BROTHER
central.nervous.505
2025-10-31 10:20:58 +0000 UTCI have a personal anecdote which I believe supports this hypothesis that endogenous n,n-DMT is a hypoxic neuroprotectant. I'm highly confident that I've inadvertently triggered my own endogenous DMT experience. This anecdote occurred several years prior to the research within that space. Back when I used to smoke cannabis, I kept a gravity bong next to my bed on top of a little table. Whenever I wanted to take a GB hit, I'd do this breathing exercise wherein I'd take three deep breaths, and I'd unscrew of the cap of the bottle while holding in the third breath, and then I'd place my lips onto the bottle opening and exhale through my nose. Then I'd take the GB hit, and immediately sit down on my bed. This was because I'd tend to hold the hit in for a few seconds, and there would often appear mild hypoxic symptoms by the time I'd exhaled. But of course, they'd resolve quite rapidly upon the first inhalation of fresh air. Except for this *one* time, when I didn't sit down on my bed after taking the GB hit. What happened instead, was that I fairly quickly realized that my legs no longer had the strength to support the weight of my upper body, and I began to collapse in this involuntary, twisting, half-dance-like, half-seizure-like descent towards the floor, while simultaneously, I felt the sensation of the onset of n,n-DMT. I'd smoked it several times at this point, so I immediately recognized it. However, it faded away just as rapidly as it'd arisen, if not even more rapidly, when I took my first inhalation of air. Some years later, I read about the hypoxic neuroprotectant studies, and concluded that this was likely what had driven my experience. Many years later, still, I had the it-should-have-been-obvious-all-along epiphany as to why it vanished so quickly when I took that first breath. Monoamine oxidase cannot oxidize monoamines without oxygen. But all it takes is a single Inhalation of fresh air to provide more than enough oxygen to drive that very rapid metabolic breakdown.
Cameron Krout
2025-10-31 05:35:50 +0000 UTCEndogenous DMT has been supposedly detected in human cerebral spinal fluid. So there’s evidence it does cross the blood brain barrier. Barker et al. have an excellent 2012 covering the research in this area https://www.researchgate.net/publication/221867586_A_critical_review_of_reports_of_endogenous_psychedelic_N_N-dimethyltryptamines_in_humans_1955-2010
Ali Clarke
2025-10-28 19:28:38 +0000 UTCBurroughs was an interesting read, thanks!
Kevin Bauer
2025-10-28 05:49:13 +0000 UTCThanks for asking some of those tougher questions Hamilton. First thing that comes to mind when I think of ppl on an island exploring consciousness / metaphysics is a cult or religion. But based on Gallimore's response I wonder if they have adequately grappled with these outcomes? idk, it's like there's a denial, or at least a dissonance between these presuppositions of "intelligence" / "entities" ---> and what actually delving into that might entail. I guess it's possible that's just not his area of focus, but hopefully there's some people on eleusis thinking it through and establishing a protocol for these "what if" scenarios.
Arylexplorer
2025-10-27 22:38:17 +0000 UTCFascinating. I am still slightly confused about the endogenous DMT thing. From what I can gather now, there is definitive evidence showing that DMT ‘could’ be produced by the body, but no evidence that it is actually being produced, is that correct? I think I remember someone in the chat telling me that there is evidence DMT is produced by the body but no evidence it crossed the Blood-Brain Barrier. Could someone enlighten me?
Meek
2025-10-27 14:53:34 +0000 UTCElvis is in the DMT space?!
Meek
2025-10-27 14:46:45 +0000 UTCI thought that was funny when I first heard it. But Hamilton is a perceptive person, I think. (I remember him making a quiet comment about Ken Nelson and his bizzare tunnel digging, as a reflection of the type of person one might have to be to smoke toad venom for the first time ever). My husband pointed it out to me, possibly because he is wired to see the bigger picture too.) A kind of bypassy cult for the elite could develop, and with the DMT and other psychedelics it could all seem to real…. At the same time, it becomes clear to some people who take psychedelics that it’s important to live life in a grounded, ‘normal’ way.
Sarah
2025-10-27 07:54:22 +0000 UTC“do you have a plan for accidentally starting a religion or a religion avoidance technique? or are you gonna roll with it if it happens?” i love listening to your train of thought hamilton
rayah
2025-10-27 02:26:28 +0000 UTCReady Andrew's book, we'll listening to it, and he mentioned that Burroughs wrote a letter to the British Journal of Addiction called "LETTER FROM A MASTER ADDICT TO DANGEROUS DRUGS". Though Burroughs may be a problematic character, as a former Junkie myself, I'm still fascinated by the man and his life so I had to find it. I thought I would share in case anyone is interested https://drive.google.com/file/d/1FS17z45hxDq_CyfPm72k8BbEAcU7U-BR/view?usp=drivesdk
Cheminterested
2025-10-27 00:24:27 +0000 UTCI get emails
Cheminterested
2025-10-26 20:46:20 +0000 UTCthe way you both smiled when mentioning Stratford's lab 🤣
✨Lali ✨
2025-10-26 16:16:01 +0000 UTCHamilton, you SHOULD have emails sent when you drop a new episode. My RSS feed wasn't updating for you for like 2 months and I thought you were MIA.
WuzdiP
2025-10-25 21:45:03 +0000 UTCI loved the conversation about conceptual structures facilitating the DMT experience. Attending to the history of religious experience reveals both AG and HM's intuitions. Near death experience are highly culturally and personally conditioned whereas the religious ecstacy in Christian mysticsm lead to theology that rejected every classical regious categorization. Aphophantic or 'negative theology' says that everything we think or say about God's nature is false. Not a popular opinion and intellectually indefensible to boot! Eckhart is one of the most influential modern theologians while not being in contention for Sainthood by any means. It's only after the experience of DMT that the discussions about elves and Elvis become irrelevant.
brendan leier
2025-10-25 20:57:57 +0000 UTCMitch Earleywine FTW! Love you! Also Symposia calling HM a 'psychedelic celebrity' is quite telling of their capacity to do anything in good faith.
brendan leier
2025-10-25 20:21:13 +0000 UTCMe, too!
Mitch Earleywine
2025-10-25 19:10:59 +0000 UTCExistentially jarring? Time for some 5!
Mitch Earleywine
2025-10-25 19:07:45 +0000 UTC36:35 I come from the perspective of an individual who has had Drug-Induced, and Non drug-induced experiences which are similar to how you describe. I mentioned in a previous comment on your interview with Professor Dave, I have a Mood Disorder and am prone to mild delusional states. Sometimes it can be as you described it to NOT be, aliens beaming information into my head and so-on. Other times, though, it can manifest exactly as you described. An extremely recognizable intensifying of consciousness, which I relate to my manic experiences. I'm lucky enough to have things in my life which ground me to reality. This is mostly through Family and Community. I live with my parents and younger sister, I work with my father. My coworkers are friends of my family, and I see people I went to highschool with in the street and working in local businesses. I am very lucky to be grounded in reality, and have built ties to things which truly immerse me. And then you go onto talk about "Explanatory framework." I'm also lucky to be rather self aware, a success of my mothers parenting, and she taught me how to approach existential dread with a sense of earnest tenacity. When I feel that intensity of consciousness, I find myself jumping into it, hoping to create a model of behavior for myself in relation to the rest of the real, grounded world. To describe episodes like my psychosis experience where I thought I was being controlled by a demonic force (Which I aptly named 'The Churnoid') I wanted to find a source of Language which was distinctly removed from what induced it (Chaos Magick and Psuedospirituality). This led me down two different roads: Rediscovering my love for the works of Ralph Waldo Emerson and his Transcendentalism, and immersing myself in the works of specifically Husserl and Heidegger. With husserls description of immanence (A distillation of the internal human experience, observed through an intellectual mechanism called Bracketing), I had language to describe my extreme conscious states. With heideggers description of pursuit of authenticity, and his Being-in-the-world (German: In-der-Welt-sein) I had something to bridge reality and my internal experience. And Emerson offered an emotionally potent starting point for me to understand Thought-Constructs, and the maleability of them despite their very real-world impact. By doing my own intellectual work, I bridged emersons romantic-era conceptualization of Transcendentalism, Husserls Immanent Phenomenology, and Heideggers bridging of Immanence into Reality to create my own sensory framework (Later dubbed I.M.T). This system functions as the philosopical and methedological backbone of all of my artistic expression. I.M.T Has gone on to become a vocabulary for describing many, many aspects of my life. I'm really proud of it. It's the culmination of a lot of thinking, like that one statue. Sorry for the tangent, but that one point evoked a lot of things I've already thought about, since I feel as if it weren't for this vocabulary I've developed, I would have been stuck with the same kind of discomfort you described.
caesaroftampa
2025-10-25 17:01:38 +0000 UTCAh been excited for this! I can’t wait to read his new book. By the way Hamilton, as you get a lot of messages just wanted to say again Andy Letcher said he would be delighted to speak with you, and I emailed hamiltonsresearch with his university email. (He also said, ‘Rock and Roll!’
Meek
2025-10-25 12:22:53 +0000 UTCI just attached the reference. The window of time between the death of the man and the discovery of valium was smaller than I remembered. The brain came from a 36-year-old man with epilepsy who died of pulmonary embolism in February 1959, diazepam was not synthesized until (in diazepam inventor Leo Sternbach's own slightly vague words) "near the end of 1959" and wasn't introduced to the pharmaceutical market until 1963.
Hamilton Morris
2025-10-25 05:21:56 +0000 UTCWOW. I used to go to St. Vincent fairly often as a kid through my twenties because I had family who would teach at the college there for essentially a free vacation. I bet I already know where they’re looking to do it, and Young Island is the perfect spot for this.
cam williams
2025-10-25 02:39:40 +0000 UTCI'll pre-emptively vote yes on voting for a vote to be conducted on continuing the rants. The lengthy preambles are crucial to a proper podcast, what else am I gonna brew my coffee to
Keenan Troll
2025-10-25 02:33:55 +0000 UTCReally interested in the endogenous benzodiazepine papers/content! Investigating the brains of cadavers from before diazepam's invention is a clever approach
Mycelial
2025-10-25 01:58:42 +0000 UTCAnd it's narrated by the man himself. Brilliant!
Cheminterested
2025-10-25 01:48:22 +0000 UTCI bought Death By Astonishment on Audible. I can't read books without falling asleep, but I do enjoy audio books. Look forward to it.
Cheminterested
2025-10-25 01:46:55 +0000 UTCBurroughs was a pedophile, my friend used to live in his house and said there was a safe full of child pornography. He also killed his wife and horrifically neglected his son. Great writer though!
Hamilton Morris
2025-10-25 00:51:30 +0000 UTCYeah, it’s discussed in an upcoming interview
Hamilton Morris
2025-10-25 00:49:20 +0000 UTCAndrew got a letter too!!
Hasate
2025-10-25 00:31:20 +0000 UTCKind of wish you would have asked about the forward being written by Graham Hancock and why he is involved with this space. I know you said you have an upcoming interview that will deal with that topic, so maybe you're saving it for later. I can also understand why you might noy want to seem confrontation with some one like Andrew who is doing your podcast and doing good work
Cheminterested
2025-10-25 00:29:33 +0000 UTCI read the Yage Letters when I was in high-school. I seem to remember some passages that either are, or are worryingly close to descriptions of pedophilia. I might need ti read it again now. I didn't even know what DMT or Ayahuasca was back then.
Cheminterested
2025-10-25 00:17:50 +0000 UTCi’m at a concert rn but i will be watching this as soon as i get home hamilton!!
rayah
2025-10-25 00:12:41 +0000 UTCI admire your passion on those topics... I'm not a chemistry nerd, but glad to support you on your journey. <3
DR4GON8IT3
2025-10-24 22:58:58 +0000 UTCStay safe Hamilton, these Symposia people don’t seem to be wrapped too tight.
Johan Elverby
2025-10-24 22:09:08 +0000 UTCBeautiful content
Inspector Fridge
2025-10-24 21:10:59 +0000 UTC
