In this episode I describe my own impressions on the multibillion dollar industry that has emerged around the new-ish opioid 7-hydroxymitragynine and speak with two industry insiders, Soren Shade w...
2026-01-11 00:20:15 +0000 UTC
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Hamilton ascends the Carpathian Mountains, microscope in hand, to learn how Europeans use Amanita muscaria, and uncovers the chemistry behind a mushroom-inspired pharmaceutical.
2025-12-22 22:23:47 +0000 UTC
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In this episode I sit down with a self-taught legend of underground MDMA synthesis and former Hive member named MethylMan. We discuss Wacker oxidation, reductive amination, aluminum amalgamation an...
2025-12-19 17:19:52 +0000 UTC
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The bufotenine episode from season three.
2025-12-06 03:05:27 +0000 UTC
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In this episode I talk with tobacco researcher Patrick Phillips about his new book "Tobacco of the Emperor" which investigates the history of Japanese cigarettes and other tobacco products. We disc...
2025-11-30 19:24:22 +0000 UTC
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In this episode I talk with tobacco researcher Patrick Phillips about his new book "Tobacco of the Emperor" which investigates the history of Japanese cigarettes and other tobacco products. We disc...
2025-11-30 05:51:27 +0000 UTC
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In this episode I talk with MAPS phase III trial participant Becca Kacanda about her experience successfully treating PTSD with MDMA psychotherapy. The conversation covers the complexity of psyched...
2025-11-22 21:20:49 +0000 UTC
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In this episode I talk with MAPS phase III trial participant Becca Kacanda about her experience successfully treating PTSD with MDMA psychotherapy. The conversation covers the complexity of psyched...
2025-11-20 07:54:36 +0000 UTC
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In this episode I sit down with Cannabis researcher, grower, and entrepreneur Joel Stanley to learn about the massive shift in public perception of Cannabis that occurred after the therapeutic effe...
2025-11-09 21:04:44 +0000 UTC
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In this episode I sit down with Cannabis researcher, grower, and entrepreneur Joel Stanley to learn about the massive shift in public perception of Cannabis that occurred after the therapeut...
2025-11-09 07:00:20 +0000 UTC
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Please enjoy the ibogaine episode from season three
2025-10-28 00:41:07 +0000 UTC
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This is a great and far-ranging discussion with chemist and neuroscientist Dr. Andrew Gallimore about his continuous DMT infusion project (DMTx) and his new book 2025-10-24 21:09:02 +0000 UTC
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This is a great and far-ranging discussion with chemist and neuroscientist Dr. Andrew Gallimore about his continuous DMT infusion project (DMTx) and his new book 2025-10-24 18:55:31 +0000 UTC
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Hello everybody, the subscriber Q&A returns!
Record audio of yourself asking a question (the question recording can be no more than 30 seconds) and email it to the podcas...
2025-10-21 21:18:08 +0000 UTC
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Please enjoy the Synthetic Toad Venom Machine episode from season three, part one from season two will be uploaded soon.
2025-10-20 16:46:21 +0000 UTC
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Please enjoy the Ultra-LSD episode from season three
2025-10-15 06:25:28 +0000 UTC
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Please enjoy the methamphetamine episode from season three
2025-10-12 21:51:33 +0000 UTC
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In this episode I sat down with chemistry educator and pseudoscience debunker Dave Farina of the popular YouTube channel Professor Dave explains. We discuss the threat of disinformation, how to pro...
2025-10-10 21:44:15 +0000 UTC
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In this episode I sat down with chemistry educator and pseudoscience debunker Dave Farina of the popular YouTube channel Professor Dave explains. We discuss the threat of disinformation, how to pro...
2025-10-10 18:34:21 +0000 UTC
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In this episode I talk with DMTx test subject and psychonaut Carl Hayden Smith about his experience as a participant in Dr. Chris Timmermann's DMT infusion research at Imperial College London. The ...
2025-09-30 05:19:00 +0000 UTC
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A few patrons requested I upload all the episodes of Hamilton's Pharmacopeia. I don't want to overwhelm the feed with episodes or make patrons feel spammed with notifications about new uploads so I...
2025-09-18 07:50:44 +0000 UTC
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In this interview with Dr. Rick Doblin (almost one year after the last interview) we discuss the recent release of the (formerly) private letter the FDA sent to Lykos after the rejection of MDMA, w...
2025-09-07 02:29:30 +0000 UTC
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Last fall, The Shulgin Foundation invited me to film the synthesis of some compounds in Alexander Shulgin's lab in an effort to teach the public about about Shulgin's chemistry. Over two days I fil...
2025-08-20 20:26:07 +0000 UTC
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In this episode I visit the home of MAPS founder and president of Dr. Rick Doblin to discuss the FDA's rejection of MDMA and the future of the drug's medical development.
2025-08-04 18:12:08 +0000 UTC
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In this episode I interview Dr. Panaccione, Professor of Plant and Soil Sciences at WVU Davis, about a newly discovered lysergamide producing fungus his student Corinne Hazel isolated from mornin...
2025-07-14 00:41:01 +0000 UTC
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Late last year mushroom educator Willy Myco released one of the strangest and most provocative chemistry videos I've ever seen, an apparent LSD synthesis tutorial filmed in Pakistan. Despite the vi...
2025-06-09 03:39:07 +0000 UTC
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In this episode I spend three hours talking with the ex-hacker, anti-snitching activist, and NMDA-antagonist aficionado Stephen Watt about his experience writing computer code while high on ketamin...
2025-06-01 04:07:24 +0000 UTC
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In this interview I talk with former Cybin chemist and pharmacologist Dr. Josh Hartsel about his work exploring the serotonergic structure-activity relationship of novel sulfur and selenium contain...
2025-04-29 22:53:29 +0000 UTC
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Hamilton is in Spain filming a three week attempt to introduce a tellurium atom into a psychedelic molecule, he planned on releasing an interview today with Dr. Josh Hartsel but a multinational mun...
2025-04-29 04:37:39 +0000 UTC
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In this episode I visit the Brooklyn home of Caveh Zahedi, director of the films "I Am a Sex Addict" and "
2025-04-01 19:21:59 +0000 UTC
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