POD 79: June Q&A and an update from the MAPS conference
Added 2023-06-30 02:37:31 +0000 UTCHere is the newest patreon subscriber Q&A, we discuss pharmahuasca, psychedelic disruption of thermoregulation, fork sodomy, regional variations in amphetamine synthesis, and more!
Note: salt stoichiometry could also be determined by X-ray crystallography, melting point (probably), and other means but NMR seems like the fastest, easiest, most reliable method.
Comments
That’s blown my mind about the nitroethane situation over there! Rah!
rabidreject
2024-09-20 11:32:04 +0000 UTCthis is the way
Pvt. Idaho
2024-05-03 18:10:59 +0000 UTCI wish there was some sort of video on these podcasts, my tv is always dark and I get so bored quickly
Joe
2024-04-24 09:05:07 +0000 UTCHi Hamilton, New member to the Patreon here, so I'm catching up on older content. Regarding the Strassman paper on administering DMT with pindolol, I think there's more to the story here: DMT appears to have neither affinity for the 5-HT1A in radioligand testing (see the Supplementary Information for "Psychedelics and the Human Receptorome") nor potency in functional testing (see compound 6 in "Interaction of psychoactive tryptamines with biogenic amine transporters and serotonin receptor subtypes"). Interestingly, the Strassman paper you mention was published in 1996, at which time it was believed that that pindolol was a selective 1A antagonist. But there is a subsequent paper published in 1998 ("Pindolol does not act only on 5-HT1A receptors in augmenting antidepressant activity in the mouse forced swimming test") that indicates that it is also active at 1B. I'm not sure that at all resolves the mystery, because "Receptrome" paper I mentioned above shows that DMT has no affinity to the 1B receptor either. My thinking is the effect Strassman saw may have been the result of some sort of "baseline" endogenous dampening of psychedelic effects that was eliminated by the pindolol - not a prevention of DMT activity at 1A. Interested in hearing your thoughts...
Peretz Golding
2024-01-06 21:51:05 +0000 UTCNow if you mean what is the psychological risk, that would depend on the dose and the experience level of the tripper in question. In my experience, I gain nothing useful out of my trips if I skip my medication, but I have significant ADHD. For someone without it, it would either be pointless or negative / obsessive, imo. As far as legitimate scientific research… who knows. I doubt combo studies will be funded for some time to come.
Walker Goff
2023-12-26 01:18:13 +0000 UTCGood point. I think safety just depends on heart health in the case of LSD. Psilocybin doesn’t stimulate D1-3 like L, so it would probably just create a slightly speedier experience without significant cardiac risk, other things equal.
Walker Goff
2023-12-26 01:14:14 +0000 UTCI would really like more (safety) info on combining psychedelics & ADHD meds, specifically psilocybin & Adderall. Of course everyone talks about SSRI's killing trips, but there's not nearly as much out there on stimulant interaction. I agree on the benzo tip; it's not obvious why anything GABA-nergic would interact with 5HT2A/triptamine-type psychedlics in any direct way.
Peter Thomas
2023-12-20 02:31:55 +0000 UTCI am routinely criticized for taking psychedelics with my prescribed adderall and Xanax. People think Xanax kills trips (I’ve never experienced that; what would GABA do with 5HTxx?). And there is just a stupid taboo against stimulants, even if prescribed. Whatever, to each their own. I’ll do me regardless.
Walker Goff
2023-12-06 03:56:51 +0000 UTCIt brings me immense joy to hear that. Thank you.
Brian
2023-11-23 17:07:09 +0000 UTCI just want you to know that I sometimes find myself randomly thinking about this comment and it always gives me a good laugh!
gossamer
2023-11-23 17:00:29 +0000 UTCI had the chance to titrate aqueous HCl into my rough extracted moclobemide FB. It did indeed easily go into solution. It seemed to require 50% more acid than expected for the 600 mg extracted. Moclobemide does have an amide link onboard. Don't think the amide nitrogen would have been without its proton in the FB state but IDK. Data on moclobemide pK is confusing, some referencing a 10 or so and I also saw a 6.4. It was titrated to a pH of 6 with 0.4 M HCl in attempt to get a final concentration of 100 mg per ml. 600 mg is 2.23 mM moclobemide, so around 6 ml of the HCl solution should have done it. The solution retained some fine particulates after titration, no doubt from the crude extraction. It was pushed through a 0.2 micron filter (at 60C) producing a clear, barely straw colored solution that showed fine particles in solution even after the filter but in a cool beaker. pH seemed to bounce up to about 8 when that solution was measured. It was titrated again to 6 with just a few microdrops of above HCl solution and heated to 60C again but the particulates did not disappear. Maybe moclobemide aqueous solubility is not so much. I'll do some more testing and also weigh the solute from this presumed HCl solution after evaporating the water.
david
2023-07-23 17:48:34 +0000 UTCI guess my question you is, how are you labeling it NO2 euphoria and not just euphoria from the Kratom? I’m not saying you’re wrong I’m just curious how you’re separating the two.
Mason Sanders
2023-07-17 08:04:49 +0000 UTCNo, nitrous lasts about 5 minutes. With psychedelics there is deffinately a synergy that allows the euphoria from the NO2 last longer. I have experienced this same synergy with kratom.
Majdi Awad
2023-07-15 16:25:06 +0000 UTCIf you’re looking for stimulating effects, if you’re consuming raw Kratom powder (which I do not recommend) take .5-2 grams. I would recommend Kratom extracts, the shots are my favorite but I use them for pain relief and to get high. I use Kratom daily, it’s an incredible drug and has dramatically improved my life. Both on the pain front and on just a general happiness front. There are these extracts called Mint MITS. I’ve used them before, they contain 35mg of mitragynine each. At least that’s what the label says. If you eat one of those that would be the equivalent of about 2 grams of your average Kratom powder. So those would work and they actually don’t taste terrible. For shots look into OPMS or MIT freeze. OPMS is the gold standard, tastes like shit right in the pants but they’re very effective. MIT freeze tastes really good and are less potent. Long answer longer you want to try and take 10-35 of mitragynine, roughly to achieve the mild stimulant effect. Beyond that it begins to become sedating in my experience. There’s also a brand called “King Kratom” I use their extract powder, very cheap, very effective.
Mason Sanders
2023-07-14 09:28:58 +0000 UTCHey man sorry I just saw this. Don’t know if you were talking to me or not but I’ll answer it All of that color stuff largely seems to be bullshit. The only thing that has been proven to affect alkaloidal concentration is fertilizer. Mitragynine is mitragynine, it doesn’t matter if the vein is white, green, or red. The drug doesn’t magically have new effects based on the color of the vein. The veins do change color, but that is solely based on what stage of maturity the tree is in. There has been no conclusive evidence that the alkaloidal content changes in any significant way through different stages of maturity. If there is no change there, then there is no mechanism for different effects. These different effects people are reporting are dose dependent and psychologically mediated. I have noticed stimulating effects from mitragynine but only in Low doses. Of course with plants they’re all varied and have different concentrations of different alkaloids, but I’ve never seen any conclusive evidence that the color means anything or changes anything. The presence of 7-HO-mitragynine seems to be more variable but even at its peak it’s only 2% of the total alkaloidal make up of the plant. So very little of that substance. However it is an active metabolite of mitragynine. It’s also more potent, and a full agonist of the MOR. So the more a person takes the more relaxed they will come. In my experience all opioids are stimulating in low doses. But the MIT to 7-HO-MIT metabolic process is capped, it does reach a ceiling which seems to mediate the respiratory depression properties of Mitragynine and Kratom as a whole. Hope that answered your question
Mason Sanders
2023-07-14 09:14:57 +0000 UTCHM, don't know why you mentioned that but that is the answer to a problem! 4 tablets were extracted - 600 mg with MeOH, centrifuged, microfiltered, dried and the resulting 585 mg would not hydrate. The molecule does look like something that would be water soluble as a salt. The chemical from the pills is a bit waxy, so yeah, I'm pretty sure you are right. I know it's hard to evaluate a pH on that but the attempt at hydration showed a litmus paper pH of about 8. Indeed the bottle just says 'Moclobemide 150 mg'. Will get a report later today on what happens with a titration of HCl.
david
2023-07-13 13:40:31 +0000 UTCInterestingly, I think moclobemide is distributed as the freebase in pharmaceutical tablets
Hamilton Morris
2023-07-13 03:48:52 +0000 UTCThat certain picture has quite a perfect symbology for a pictorial represention of the phrase "men are pigs".
Honey-el
2023-07-13 01:52:36 +0000 UTCWow thanks so much for answering my question re feeling cold, and for shedding some light on why it occurs w some drugs and doses and not others. Hearing that people think they’ve peed their pants is news to me but I have experienced not being able to pee my pants while on MDMA, another strange phenomenon !
opperdister
2023-07-11 19:10:04 +0000 UTCHad no idea that existed, thanks. (On Android.)
CSN
2023-07-09 00:07:50 +0000 UTCMaybe TMI for this thread but I'm wondering if you find kratom useful as a (mild) stimulant as there seem to be different types designated by red, yellow, green, etc. And if so, what 'type' and what dose would a mytragynine naive individual start with to seek this effect?
david
2023-07-09 00:00:29 +0000 UTCNo, I'm sure he refers to oral administration of moclobemide followed by 'smoking' of the DMT freebase. As I mentioned above, 'Changa' is the 'smoked' combination of naturally occurring harmala alkaloids with, typically DMT FB. Australian, Julian Palmer has good accounts of the history of and a book on this and I believe he stakes a claim to have first 'invented' it . . . or at least first written about it. It does put an interesting perspective on the combination of these two classes of alkaloids from ayahuasca to Changa to 'smoking DMT'. Moclobemide would require some work to extract from its tableted form followed by, I presume, changing the salt to the FB for 'smoking'. Moclobemide / DMT, however, does lend itself to the concept of a totally parenteral pharmahuasca.
david
2023-07-08 23:54:29 +0000 UTCIn my limited experience Calea z. made my sleep quality terrible so I chalked the vivid dreams (and their recall) up to being stuck in a very shallow state of sleep. It is also the absolute worst thing I've ever tried to drink. Tastes like potpourri smells. I will powderize and capsulize when I try again someday, I don't care how many 00s I have to choke down.
CSN
2023-07-08 23:53:53 +0000 UTCAhh I assumed he was speaking about smoking the DMT and the MAOI. Are there any reports of people trying something like that?
Mason Sanders
2023-07-08 23:24:01 +0000 UTCAdderall is 75% (S)-dextroamphetamine, the rest is the R. IDK how or why they arrived at that combo. But they did. Seems they take a mixture of half racemic amphetamine plus half dextroamphetamine and . . . that is adderall. Perhaps someone else can shed some light on that. I've wondered. BTW, if you are wondering if pure dextro is 'better', I think you would not notice the difference. It is an available drug called benzedrine which is just the dextroamphetamine. It's a whole 'nuther discussion, but I believe that Desoxyn has a edge over Adderall but it is hard to get because nobody prescribes and thus it's just not stocked. It is the dextro enantiomer of methamphetamine and the conversion is about 0.75 :1 Desox to Adderall although you will read that it's 0.5 to 1. (W:W). It is a subtle difference but then, we are talking about subtle differences aren't we re Adderrall vs Benzedrine vs Methyphenidate. And in case you are wondering . . . no big whoop about it being 'meth'. Taken in reasonable ADHD doses of 10-20 mg, it' s just a softer touch to it, more anxiolytic, I guess. Hamilton is right . . . most people might not notice the diff but I'd say that in a bigger study, it would show a difference. I'd love to do that study not only to dispel some drug mythology but to bring this drug back to availability. If a popular OTC decongestant was reduced into amphetamine then amphetamine would be stigmatized drug and Adderall might be methamphetamine.
david
2023-07-08 00:26:26 +0000 UTCThank you for the suggestions David. Now, I wonder how much of my 20 mg Adderall XR equals 7.5 mg of d-amphetamine?...
Peter Thomas
2023-07-07 23:40:26 +0000 UTCI think Hamilton Morris discord chat would be a good idea.
Lukas Danys
2023-07-07 16:53:45 +0000 UTCHamilton, just wanted to say how much I enjoy your work, and your closing quote was priceless! I got a good loud laugh out of it.
Kevin Bauer
2023-07-06 20:02:28 +0000 UTCTaking 300mg of moclobemide one hour before smoking DMT dramatically increases the duration, making it at least one hour, but due to the smaller dose ingested (typically) it seems that it is more rapidly redistributed out of the brain and metabolized (likely via 6-hydroxylation).
Hamilton Morris
2023-07-06 18:26:50 +0000 UTCVitamin B6 had massive effects on the intensity of my dreams... did not have any effects with calea
Aidan
2023-07-04 14:43:17 +0000 UTCEvery extract I have tried has been a complete waste of money ngl. But either way I need ways to stop myself taking more and use it as a very effective tool (rather than eating as much as poss and being unproductive and smoking a thousand cigarettes aha). Thanks tho
Meek
2023-07-03 17:26:47 +0000 UTCI agree with David. The problem is that amphetamine is incredibly potent, so the slightest increase in dosage could drastically change the experience. If anyone were to do this, I would suggest doing it with methylphenidate, just like the study mentionned by Hamilton and Jordon. However, I suspect that positive effects would mostly be observed for ppl with ADHD. For control groups I would you could still observe positive experiences, but the odd of the experiences to be positive should be higher for ppl with ADHD since they use Ritalin as medication. For ADHD patients that don't use Ritalin because it doesn't work for them, let it be replaced by their treatment. However, how about psychedelics that acts on both serotonin and dopamin circuits? Is there any compounds out there that has been screened for both HT2A and DAT? Or any other pathways to increase dopamine concentration at the synaptic cleft?
Paul
2023-07-03 06:35:51 +0000 UTCBased off some very quick research smoking DMT with an MAOI does increase the duration but slightly. That would likely be explained by the well known phenomenon of “the quicker the onset, the shorter the duration.” So the lungs do absorb them, but they’re also cleared out of the body, or at least the brain, quicker. This is why smoked cannabis doesn’t last as long as edible cannabis, or smoked Methamphetamine doesn’t last as long as orally infested Methamphetamine. Of course if you’re going to do this make sure you’re not on SSRIs or any other drug that effects the concentration of serotonin in the brain. If you would like a deeper answer or have any other questions just let me know. Im working 13 hour shifts and am not doing too much so I’d love to talk more. I am working Night Shift though so my responses may be late in the day.
Mason Sanders
2023-07-03 06:11:34 +0000 UTCI always thought that it was about vasoconstriction rather than 1A agonism. Espcially that the worst shivers I've ever had was on 2cb
Paul
2023-07-03 06:08:44 +0000 UTCOne of my favorite parts of talking to people and listening to podcasts about drugs is hearing people pronounce them differently. I didn’t even recognize word mitragynine at first when he said that lol. I pronounce the A like someone does when they say drama. Not when they say at.
Mason Sanders
2023-07-03 06:06:54 +0000 UTCI take Kratom daily, it’s my favorite drug ever. I would want to ask if you think it’s actually increasing the impact of these drugs, or is it just adding another layer to experience? So if you’ve taken those drugs alone or with a different substance, and then switch up your combination, of course it will feel different. That doesn’t necessarily mean it’s increasing the dissociative effect, it’s just another psychoactive substance in the brain. However, with these types of conversations it’s hard to boil it down to technical pharmacology and neurochemistry and usually relies on what the person is feeling subjectively. So if you feel it is doing that, then that’s a definition you have assigned to the feelings you are experiencing while combining these drugs. It’s not necessarily right or wrong it’s just you reporting how you feel. It’s like how some people say cannabis makes them sleepy and feel brain dead, while others say it makes them creative and gives them energy. They’re both right, and there’s not really a way to explain it pharmacologically. Instead it’s just the users input on the experience.
Mason Sanders
2023-07-03 05:55:26 +0000 UTCSo the simple answer to this question, at least as to why ayahuasca or edible DMT experiences last longer is because MAO doesn’t just exist in the gut. It also exists in the brain and will breakdown DMT even in the brain, unless it is inhibited. So when you smoke DMT, MAO will break the drug down very rapidly. Where if you inhibit MAO it will be able to sit on the receptors and exert a pharmacological effect for longer. This is also why psilocin (4-HO-DMT) will last longer than DMT itself. The hydroxyl bond at the top of the molecule effectively blocks MAO from breaking the molecule down. Does tbh at answer your question? I am also not aware of people smoking DMT with an MAOI, I will look into it more and try to come back to you. If it doesn’t cause the experience to last longer there could be a variety of reasons for that. Whether it be that the lungs don’t absorb these drugs enough, maybe they don’t fully vaporize, maybe they’re burned off and broken down, etc. i will try and come back with a good answer on that topic.
Mason Sanders
2023-07-03 05:51:38 +0000 UTCWell speaking of Hamilton telling people to ask questions. I have studied pharmacology and neurochemistry related to drug use for years, been working on a book on the topic for 3 years now. If y’all have any questions Hamilton hasn’t been able to respond to, I’d be happy to attempt to help out. Not trying to toot my own horn or anything mainly just very bored at my job working 13 hours a day and have a lot of time on my hands and love these conversations. So please any questions, shoot them my way I’ll be happy to try and help.
Mason Sanders
2023-07-03 05:42:53 +0000 UTCInstead of using normal Kratom powder you should really look into extract powder. Particularly the king Kratom extract powder. It’s roughly 5x as strong per gram. It’s very cheap, and very effective. One gram of it does feel very similar to 5 normal grams. I usually take 2-4 grams of it. There’s also extract shots that are amazing as well. They Kick in very quickly.
Mason Sanders
2023-07-03 05:40:23 +0000 UTCHamilton or others - re Pharmahuasca, Moclobemide certainly blocks gastrointestinal MAOs and allows DMT to make it out of the GI tract to become systemically available. Do you have a sense of to what degree mecobemide *also* enhances the systemic effective duration / half life of DMT? It appears to enhance the systemic duration. Else why would the pulmonary route of administration of a similar, say 50 mg DMT dose, simply last 15 minutes while pharmahuasca duration is on the order of hours? Some might care to comment about Changa, the smoked combination of DMT (and sometimes some 5-MeoDMT) and an MAOI, typically mixed harmaloids on various herbs. I'm not so knowledgeable about this.
david
2023-07-02 17:25:32 +0000 UTCYou can still buy small amounts of Nitroethane at S3Chemicals afaik. https://shop.es-drei.de/alkane/13920/nitroethan-min.-99-5?number=S1003000.05
Psychestim
2023-07-02 09:51:41 +0000 UTCI’ve had life long issues with parasomnia behaviours (walking, talking, hypnogogic/pompic hallucinations) and it’s something that appears to be genetic (my mother has same issues). Medicinal cannabis oil recently helped to reduce these dramatically, but I never considered the acetylcholine system as a cause/treatment target. Will have a look into this in general.
Jai Whelan
2023-07-02 06:16:00 +0000 UTCShould have done the Seinfeld joke.
cramwich
2023-07-02 03:44:16 +0000 UTC👏🏻
Tanner
2023-07-01 09:32:43 +0000 UTCPertaining to Kratom, my experiance, as someone who has used kratom daily since I started to wien off of prescription opiates, benzos and Amphetimines in 2018. In my experiance... Kratom undeniably enhances the disassociative impact of N02 and Ketimine. Somewhat enhances MDMA in the way that it has a calming effect so makes the comeup more smooth, yet is a stimulant, so its not like taking a typical opiate with MDMA. Outside of that, found that kratom has had a negligible impact on Psylicibin, LSD, and DMT. At the end of the day, some combinations are used incorrectly as it is a delicate science or one, or a combo of stronger drugs will absolutely outweigh the lighter impacts of one or a combo of the drugs being used. I.e. smoke 200mg dmt, no combo is going to really impact you, atleast in a scientifically recordable way. Love anyone else's imput on this subject.
Majdi Awad
2023-07-01 06:16:23 +0000 UTCLove this very much. I hope he takes you up on it, Hamilton.
Samantha Firoze Sethna
2023-07-01 05:54:39 +0000 UTCSorry for the following long dialog but you hit so many topics and some of my favorite. Thank you for the thorough pharmahuasca overview. Very informative. Yes moclobemide (MAO-BI) is it. Why do traditional aya except perhaps for the cultural experience. BTW moclobemide is not available in the US market. Canadians have it and will ship to US with a legit doctor's order. Have played with the available (MAO-BI) selegiline and can say definitively that selegiline does not work orally with DMT. Re shivering, this is a favorite of mine - yes, psychedelics can cause shivering on the come-up, typically the tryptamines in modest to higher doses although it seems 2CB and likely other phenethylamines may have that effect. I assume it is similar to pyrogens and other processes that change the hypothalamic thermostat. *** I am in no way endorsing or suggesting the use of the following anecdotal information for therapy *** Rre shivering, meperidine is fantastic @ 12.5 - 25 ms SQ as is Doxapram @ 20-40 mg. Dantrolene 50 mg SQ is effective as well. The latter is not available as a common parenteral med and must be custom compounded by methanol extraction from the tablets then diligently hydrated to a 100 mg/ml solution, 0.2 micron filtered for injection with appropriate sterile compounding precautions and stored with benzyl alcohol 10 mg/ ml for use after 24 hrs. Meperidine and dantrolene are also effective for MDMA bruxism but meperidine wears off after a couple of hrs and is a controlled drug. Pindolol - I think lots can be done with this drug. It's a fascinating story, the connection between pindolol and propranolol and psychedelic research in the 40's I think. These two beta blockers differ by an indole vs a napthalene moiety. "Twelve volunteers received a sub-hallucinogenic dose, 0.1 mg/kg, i.v. DMT, or saline placebo, in combination with 30 mg oral racemic pindolol, or placebo-pindolol, in a four-cell double-blind, randomized design. Volunteers found that pindolol pre-treatment enhanced D M T effects by two to three times, which was substantiated by scores on the HRS, in which four to six clinical clusters demonstrated a significant enhancement by pindolol." Another favorite topic . . . A stimulant enhances a psychedelic journey as Hamilton so aptly describes. Take note! The take home message, insight and integration is what counts in a meaningful psychedelic journey. Get the most from your journey. IMO as well, modafinil as well as classic stimulants also enhance a 2a trip with improved 'recall' and attention to insights and the often demanding firehose of existential download you may receive. They also reduce fogginess or sleepiness you may get on a 2a trip as he notes - yes. Some folks may not have this problem. I do. This combination *also* works remarkably well even with a diminutive ADHD combination of a stimulant and 2A agonist. Ex - Pick one - 5 mg methyphenidate 50 mg modafinil or armodafinil 7.5 mg dextroamphetamine 5 mg dextrodesoxyephedrine with 7.5 mcg LSD 0.625 mg psilacetin or equivalent mescaline? - suggest a dose Thank you for some great discussion!
david
2023-06-30 23:43:17 +0000 UTCI have not tried nicotine patches and sleep since school days and I am doubtful I will anytime soon. I actually enjoyed most of the experiences I had but it is so demanding I would struggle to bring myself to repeat it. 10/10 recommend to anyone 🫠
Meek
2023-06-30 23:03:15 +0000 UTCThank you so much for answering my kratom question!
gossamer
2023-06-30 22:46:48 +0000 UTCInteresting to hear about kratom and intensity of experience questions: (for quick context I once threw up from one small P. semilanceata, I have some weird intolerance/sensitivity to them). First time I ate mushrooms properly I had just returned from India aged 19 and been eating LSD a fair amount so thought I was captain Trips. I consumed somewhere in the range of 40-100 semilanceata in a lemon infused tea, and within 5 minutes my teeth were floating around my mouth and my tongue was licking itself. I ended up taking two etizolams (can’t remember dosage) and about 25 grams of kratom to calm myself down and it really brought it down. But that was probably enough sedation to take down a fentanyl tolerant rhinoceros. Interestingly, years later tapentadol experiences seemed reminiscent of that rather fractaling mitragynic evening.
Meek
2023-06-30 22:32:43 +0000 UTCNothing wrong with a 2A agonist and a stimulant. "Dangerous" is a bit of a strong word IMO. And if taken at the same time, one would be prudent, not for safety, necessarily, but for the sake of experiential research, to reduce the dose and vary ratio of each while noting your experience. The added mindfulness is also therapeutic in your goal towards better focus or productivity and can be a lot of fun. Psychosis from such would IMO be far from concern with incremental and mindful attention to the process. I'm not being critical of your question, there is some logic in it for sure.
david
2023-06-30 21:40:19 +0000 UTCThanks Hamilton!
Peter Thomas
2023-06-30 21:20:45 +0000 UTCYeah, it’s true, mitragynine contains a 4-MeO-tryptamine backbone but has a lot more structural complexity beyond that.
Hamilton Morris
2023-06-30 21:15:27 +0000 UTCYeah, you’ll get first dibs
Hamilton Morris
2023-06-30 21:03:56 +0000 UTCOk, for anyone wondering, hit the compass button down the bottom, then click on Hamilton's podcast, then you will find the community tab 👍👍👍
Aidan
2023-06-30 18:56:21 +0000 UTCThere was a group doing doing LSD + methylphenidate therapy back in in the heyday of legal psychedelic therapy. Apparently it was pretty successful. I know that's a little different from what you're talking about but interesting...
5hydroxytryptameme
2023-06-30 17:24:27 +0000 UTCStarting the pig head fan fic today
avery maynard
2023-06-30 16:53:33 +0000 UTCThank you so much for taking my question Hamilton! The question of why is Europe (save for the Czechs and Slovaks) the exception of methamphetamine use over amphetamine use illicitly has deeply bothered me since I first learned what "euro speed" is. A few of things I'd like to bring up in addition to your insights. Street speed is incredibly low purity. If you've ever had the displeasure of being in the same room as some speed your nose will tell you its impure by the pungent floural odor of phenylacetone or occasionally an unbearable fishy smell. The average purity of amphetamine samples encountered in Europe is just about 24%, where as methamphetamine samples encountered in Europe have an average purity of 50%(¹). Now why is purity for amphetamine this low? Most likely because street speed is made of already low purity amphetamine that then is cut to death. So you would think the potentcy difference would make a substantial effect on what would be prefered by dealers and users (more room for cut, and more doses per gram). Yet amphetamine is still the prevalent option. It's also notable that the use of methamphetamine in Europe predates that of American methamphetamine use. The most notable example of this being of course the German Pervitin, 3mg methamphetamine tablets avaliable over the counter that were wildly abused in Nazi Germany. Another country who's use predates the American use of methamphetamine is the country in which it was invented, Japan. In Japan methamphetamine was formulated under the brand Philopon, and damn is it difficult to find information on dosage or availability besides the fact it was used by factory workers and soldiers. The difference in the methamphetamine usage between Japan and Germany is that the Japanese still prevalently use methamphetamine over amphetamine illicitly. And as one last note, it seems that (at least according to precursor seizure data) amphetamine in Europe is usually made from phenylacetone(²) (hence why it usually reeks of it), which is just just a single reductive amination away from methamphetamine OR amphetamine, but yet amphetamine is still the chosen chemical. All of these things are just to add to the point of how strange it is that amphetamine is the chosen chemical in Europe and how youre 100% correct in that drug trends make little to no sense! Thank you again Hamilton. ¹ https://www.emcdda.europa.eu/data/stats2017/ppp_en ² https://www.emcdda.europa.eu/publications/european-drug-report/2023/drug-supply-production-and-precursors_en
Troy Singleton
2023-06-30 16:50:24 +0000 UTCHamilton please take precautions as to not be forked in the ass
David James
2023-06-30 16:09:56 +0000 UTCI’ve never tried nicotine patches, but this does make me think of the fact that Kratom almost always gives me horrendous sleep paralysis if I take it close to bedtime. I was a weekly Kratom user for a long time without that issue, in fact drifting into sleep was very pleasant, but the sleep paralysis propped up in the last few years (decreasing my usage further).
Brendan K
2023-06-30 15:59:54 +0000 UTCI’m looking forward to the booklet / merch. Hopefully Patreon supporters get first dibs (and if they do, it might encourage more to sign up).
Brendan K
2023-06-30 15:56:02 +0000 UTCa couple of years ago, I was able to get something that my dealer referred to as "sulphate" which was much nicer than the regular speed he was selling - almost no edgy effects at all, I used to say that if you did too much you would only know because you would suddenly realize that you were going to be awake for a very, very long time. I had thought that regular street speed in comparison was amphetamine hydrochloride, but now I'm not so sure.
Kay Smoljak
2023-06-30 15:40:34 +0000 UTCIt’s in the iPhone app, probably in every mobile app for patreon
Hamilton Morris
2023-06-30 15:37:06 +0000 UTCAnother delightful episode! Thanks, Hamilton
mia
2023-06-30 15:21:44 +0000 UTC+1 I've only seen it discussed as a potentially dangerous combo, increasing the chance of getting stuck in thought loops, but the "externalizing the experience" tidbit is intriguing. Especially, how much the slight cognitive reframing of the amphetamine interaction could play a role in the outcome (seeing it as a positive, synergistic effect) vs. a purely neuropharm lens. Anecdotally, I've experienced an episode of what could potentially be classified as acute psychosis with the combo and have avoided it ever since. At a much lower dose of amphetamine (combined with a low-moderate dose of psilocybin) I didn't experience any adverse effects, though I wasn't as stringent in my documentation of an experience as I am now.
mia
2023-06-30 15:18:59 +0000 UTCThere's a couple of things that always boggle my mind related to this question. Firstly it's always the question of 'why is Europe (save a few countries) the exception of methamphetamine use over amphetamine illicitly', as you said ease of consumption through snorting or bombing is great, however yaba methamphetamine tablet are used as a "club drug" in Asia where it can be taken just as discreetly in the same context. And the other thing that always gets me with this is that Europeans had a culture of methamphetamine use BEFORE the United States did, yet that is not the case any more. I will add as a note of personal taste I believe amphetamine overall is a better drug to use, shorter duration, not as edgy with effects, and overall just more mellow and productive. So I can understand why someone would make the cognizant choice to choose one over the other. Thanks for your input because this question has always bothered me
Troy Singleton
2023-06-30 15:08:43 +0000 UTCSomething I recently noted in Christian Ratsch's "The Encyclopedia of Psychoactive Plants" was that "Mitragynine is chemically related to psilocybin and other ergot alkaloids (D. McKenna 1995, 102*)." Aside from Dennis's (probable) unintentional confusion of psilocybin with ergot alkaloid in the original quote, the attenuation of 5HT2 via 5HT1 agonism you mentioned is surprising!
Peter Thomas
2023-06-30 14:57:53 +0000 UTCFor the ADHD crowd, I would love to know more about the safety of combining 5HT-2A psychedelics (specifically psilocybin & LSD) with amphetamines. Considering the psychosis liabilities involved, I'm surprised at the paucity of information out there on this.
Peter Thomas
2023-06-30 14:48:54 +0000 UTCI always thought that elevated body temps explained the paradoxical chilled feeling when you have a fever. In other words, if your body temperature is higher, the surrounding environment should feel relatively colder. Perhaps the dose-dependent response of 5HT-2A agonists on body temperature corroborates this hypothesis? Curious what specific dose ranges for humans you meant by high vs. low doses.
Peter Thomas
2023-06-30 14:35:55 +0000 UTCIm just a baby and it's a long road ahead to get to the level of a lot of people in here but I want to say that hearing people in these q&a's talk about stuff I have adjacency to but no one irl who shares interest makes me feel a lot less estranged so ty for the therapeutic effects. Sry english not 1st language
Riki Sharma
2023-06-30 14:34:17 +0000 UTCHello all! I posted this on the community page, but I am a user-experience researcher currently researching recreational substance use and looking to recruit participants for this study. If interested, please fill out the screener survey linked below (and feel free to share the link with others who may be interested). Experience with psychedelics or other substances is NOT necessary for participation in the study. Thanks! :) https://forms.gle/2kU7DZvS4xXtevBx9
mia
2023-06-30 14:13:41 +0000 UTCI think you have to access it from web :/
mia
2023-06-30 13:47:41 +0000 UTCThe bit about how the 2A vs 1A ratio alters body temperature effects was so interesting. I’d love for allylescaline to be assayed. It causes more body temp fluctuations than most other psychedelics and also seems to have a ceiling effect (and mild activity to begin with) A biologically complicated 1A:2A affinity ratio could explain that. Edit: To weigh in on kratom question- IME mitragynine blocks psychedelics to a decent extent, however kratom tolerance greatly potentiates psychedelics. Kratom also absolutely can contain psychedelic adjacent alkaloids. The psychedelic effects become most apparent with low tolerance and high doses and adding cannabis. There are visual pattern effects far beyond cannabis alone
Andy
2023-06-30 13:15:06 +0000 UTCFor the love of all that is holy, please share your thoughts on Bob Lazar with him. My eyes roll into the back of my head every time it comes up.
Ryan Campbell
2023-06-30 12:18:22 +0000 UTCAbout the US vs Europe amphetamine question: I live in Germany, and speed is ubiquitous: extremely cheap, easy to get, and when snorted or mixed in a drink, far easier to consume in clubs or at parties or in parks than smoking meth - no additional apparatus needed and you can do it in a bathroom or discreetly in a dark (or not so dark) corner. Meth is available here, but it's not as common - and try snorting crystal meth, it's not a pleasant experience. So I think it's definitely a cultural and historical thing, and I'm personally pretty happy about that.
Kay Smoljak
2023-06-30 10:41:15 +0000 UTCThank you Hamilton as always for putting out your podcast. It is always a treat that I look forward to, makes my day at work a lot better. I know that this doesn't solve any of the actual problems you have but just know that even if there are people who are against you, there are also others out there that know you have good intentions and have their days improved by what you do.
Benjamin
2023-06-30 09:26:49 +0000 UTCAbsolutely. But at the same time you deserve to be respected.
Sage Warren
2023-06-30 09:01:42 +0000 UTCThe one thing I don't like about patreon is the lack of a forum page or whatever, I think this group would be awsome as a forum... my app doesn't have a community tab like Hamilton mentioned... how can I find that?
Aidan
2023-06-30 08:27:12 +0000 UTCCalea zacatechichi never worked for me. Nicotine patches on the hand would wake me up in the middle of the night with a screeching Cousin It next to my bed. I had to take the patch off before sleeping after that.
Gershon Kreimer
2023-06-30 07:04:49 +0000 UTCThank you for your answer, Hamilton. Certainly cleared things up.
Gershon Kreimer
2023-06-30 06:40:37 +0000 UTCYes, I'll return to JRE
Hamilton Morris
2023-06-30 06:28:09 +0000 UTCI actually like Savinelli (threats included) and I would like to have a conversation with him about all of this.
Hamilton Morris
2023-06-30 06:27:03 +0000 UTCThanks for taking my question. I see your point about how this study describes the longer-term therapeutic effects of menthol inhalation, while the entourage effect in cannabis is thought to be a more acute effect. I didn't mean to imply that cannabis contains menthol, just that the terpenes that it does contain are often credited with contributing to the entourage effect, and also have distinct aromas, as does menthol. EDIT: Here is the article that prompted my question: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1130044/full
Brian
2023-06-30 04:37:11 +0000 UTCI feel there must be a clue somewhere in Poe's sonnet, and now I'm going to spend too much time searching for meaning in it. Although I agree, maybe it's better not to know some things, and this sounds like one of them.
Brian
2023-06-30 04:18:04 +0000 UTCAre you gonna go back on Rogan ever? Im pretty sure he can help with all the legal stuff going on, or at least throw up the bat signal.
Steven Kellner
2023-06-30 04:00:05 +0000 UTCA positive solar wind annihilation story.
Brian
2023-06-30 03:31:59 +0000 UTCStay safe brother, we need you!
CSN
2023-06-30 03:15:21 +0000 UTCThe harassment genuinely is not okay. It wouldn't hurt to look into a restraining order. If you are facing online abuse, you may be able to request that a judge issue a restraining order to prevent the perpetrator from further harassing you. I highly doubt he will come onto the podcast. I also highly doubt after this long he will stop. Just a suggestion
Sage Warren
2023-06-30 02:43:27 +0000 UTC
