In general, Radfall doesn't make a lot of changes to the difficulty of combat. I've built it mainly to handle the survival resource aspects of the game. In LitR, I rely on Lunar Fallout Overhaul to handle the balance of the main game (and if you're running a non-LitR list I recommend grabbing it, or another similar mod like Damn Apocalypse), along with mods like Super Mutant Redux, and Gunner Outfit Overhaul, and a Dangerous Deathclaws to make NPCs that should be harder more of a challenge. However, there were a few minor tweaks I've mod on top of all that as part of Radfall.
Synths and robots take different limb damage
Ghouls take less body damage
Tweaked locational damage multipliers
No bonus sneak attack damage without perks
Adjusted minimum damage parameters, the main result is that at very high armor values (e.g. Power Armor) targets take less damage
Caps stashes randomly replaced with mines