December Q&A: DOI prohibition, 5-HT3 antagonists, prodrugs and more!
Added 2023-12-29 07:36:07 +0000 UTCIn this Q&A I discuss the DEA's new plans to prohibit DOI and DOC, Ritalin tablet prestidigitation, clandestine plant breeding and X-ray crystallography. A link to the Federal Register can be found below, enjoy!
Comments
True, not sure how I missed that: https://patentimages.storage.googleapis.com/c9/f4/7a/7aa95d76398982/US11440879.pdf
Hamilton Morris
2024-01-26 17:30:55 +0000 UTCThere is 100% pharmacological info on EPT in the Gilgamesh patent listed as compound 1 or compound 2 one is EPT and the other MET. Compounds 3 and 4 are their 5-flourinated counterparts
Keegan Crocker
2024-01-24 19:12:40 +0000 UTCI always learn at least one new little nugget when I listen. Thanks thanks thanks
tgoodjenkins
2024-01-13 02:18:07 +0000 UTCYou can absolutely develop databases for rapid dereplication and identification of NMR data. I had to do this during postdoc. It was super tedious because the NMR data either 1- had to be entered manually or 2- freshly acquired (which isnt possible if you dont have all the compounda you want to out in your datase. Its called Spektraris and should be open source. But it works very well if you put the time into building a database of compounds you expect. Either way if you could have an AI read pdf files from scientific literature this would massively help to build a giant database. The issue there is AI wont be able to notice errors in literature. If you couls build such a large database you can probably start trainimg a AI tool to help with interpretation. Also yea Mestrenova kind of sucks. hah
Justin Fischedick
2024-01-12 22:28:37 +0000 UTCThis is such a good Q & A! Glad I re-listened to it today and there is more time to comment on the forum than I had remembered.
RobotCuddleFish
2024-01-09 07:50:46 +0000 UTCI know it’s a good Q&A sesh when I’m inspired to go down a handful of new rabbit holes! Thanks Hamilton! Also lmao at the extensive vyvanse wiki being a byproduct of its own use 😂
Dasloops
2024-01-07 12:44:25 +0000 UTCHow much do you sell half a gram of DMT?
LittleRonnieStiltskin
2024-01-07 06:27:05 +0000 UTC4-aco-EPT and 4-ho-ept have a good bit more information available on them then EPT 4-aco-ept is mildly stimulating, lacking in a deep or confusing headspace. I find it useful for microdosing prior to social engagement or as an adjunct to other psychoactives Due to its versatile and mild character. Unlike many other psychedelics it can be administered alongside stimulants without inducing anxiety (for me) It is active at a 10-30mg dose for 1.5-2h.
Me
2024-01-06 04:06:45 +0000 UTCSearch for “Selegiline Phenethylamine” on reddit Lots of reports
Me
2024-01-06 04:03:34 +0000 UTCThe Lysine-β-Phenethylamine analog of vyvanse has been synthesized and assayed here Ding, Yuanyuan, et al. "Preparations and doxorubicin controlled release of amino-acid based redox/pH dual-responsive nanomicelles." Materials Science and Engineering: C 77 (2017): 920-926.
Me
2024-01-06 04:02:21 +0000 UTCWhoever asked the second question about accessible and credible information, I'd love to chat! I'm currently working on a project where that is a big issue. But if anyone else wants to participate please fill out the survey and I will reach out! Appreciate it :) https://forms.gle/ijCqM1B5GJAZk7Wp6
mia
2024-01-05 05:42:54 +0000 UTCthank you for answering my crystallography question! regarding machine learning for structure solutions, there's definitely software for single crystal XRD that have some structure solution functionality, but I don't know of anything similar for powder diffraction beyond basic peak matching with a data library as the density of defects is generally much higher in a polycrystalline materials and other pattern artifacts (i.e., peak broadening, preferred orientation, etc.). most crystallographers i know of (myself included) are hesitant to do full structure solutions from powder XRD without data collected using synchrotron radiation and/or other complimentary scattering methods like pair distribution function analysis or neutron diffraction, though I work in an exclusively inorganic materials space, so this may be different over in the organics world.
Sinclair Combs
2024-01-02 23:32:29 +0000 UTCI’ve had extremely nightmarish experiences as a result of nausea. So that bit was great to hear.
Tyler Stark
2024-01-02 15:35:18 +0000 UTCWish you and your family the best for this 2024, Hamilton.
Cyrus
2024-01-02 11:16:16 +0000 UTCIt's where the peristalsis is your stomach slows. I have had it myself before, a paralytic illeus. And my grandmother calls it a lazy stomach because it's most likely easier than explaining the medical term to an everyday person who isn't interested in medical terms
SourPatch Thurgood
2024-01-01 21:12:32 +0000 UTCWhat is "lethargic stomach" and who told you that was a diagnosis?
CSN
2024-01-01 21:06:03 +0000 UTCMy grandmother has a lethargic stomach. I know it's off topic, but is there anything whether it be homeopathic, pharmaceutical, herbal, etc. that is legal in the U.S. that you might recommend her to mention to her or her doctor for aid/relief
SourPatch Thurgood
2023-12-31 19:41:59 +0000 UTCPrayers to your family Ham 🙏🏼 Keep your head up and happy new year
Tanner
2023-12-31 09:22:03 +0000 UTCJust curious, is there anyway of interviewing Leanord Pickard. I know you said in the past you that he doesnt like to talk about any of the chemistry he had done in the past. Would you know if he would be willing to talk about the case with skinner or his view on pyschedlics at his stage in his life? I think it would be an interesting synergy with you and him
BigRigRick
2023-12-31 03:23:07 +0000 UTCI though phenylethylamine doesn't do anything but make you feel ill if it does anything at all pretty much. Where did you read about how people use it successfully and what it does?
Andrew Mackney
2023-12-30 20:45:10 +0000 UTCPeak plasma levels of ondansetron occur 1-2 hours after administration, I think pretreating 30 min to an hour before is sufficient.
Hamilton Morris
2023-12-30 18:51:00 +0000 UTCWhat timeframe before dosing a psychedelic do you take the zofran? Just curious about your personal experience
Josh Levy
2023-12-30 15:43:55 +0000 UTCIs this Steve Gill?
Hamilton Morris
2023-12-30 00:06:20 +0000 UTCSpeaking of Swiss scientists, an interview with Matthias Liechti and Dino Luethi would be amazing too.
Psychestim
2023-12-29 23:04:10 +0000 UTCHappy new year everyone! Hamilton, you mentioned the idea of using machine learning to interpret NMR spectra? Great idea for all sorts of spectroscopy, and they're on it! https://www.bruker.com/en/landingpages/bbio/artificial-intelligence-in-nmr.html. There's even a YT video called, "ChatGTP and NMR", and the applications to chemistry in general are just beginning to be tapped . From molecular modeling to alfafold, those darned stochastic parrots are gonna revolutionize things a little bit. I like the idea of incorporating biochemical steps to both simplify some synthetic pathways and create "green" alternativess. Maybe in the future we'll be trading "hot" yeast cultures instead of worrying about precursors. Is it OK to mention Sci Hub here? It's a great resource for papers over a year or so old. That probably goes for Chemical and Biological Abstracts as well, but up to date volumes should be available at university libraries ..very tedious though to search by hand! My generation grew up in the pre-digital era when digging through the immense collections of periodicals in the stacks of medical school libraries and photocopying articles of interest was a normal part of going to school. Now that almost everything is digitalized and available online it's a lot easier in some ways ....of course a five page article from the Journal of Organic Chemistry that one used to photocopy at the library for a dollar is now only available online and can cost $35.00 or more.....thus the beauty of Sci-Hub ....I feel that as long as it's for personal educational use only it's OK, but YMMV. Finally, even if the controlled substances laws were loosened it's going to be more difficult for people to explore medicinal chemistry at home than in the past in this post-Oaklahoma City, post-9/11 post fentanyl world.....and we're not even post-CRISPR yet! But hope springs eternal....Cheers ...
Steven
2023-12-29 22:20:16 +0000 UTCWow that xray crystallography bit was fascinating, what a good guy to be so helpful and make it happen! So neat
Austin T.
2023-12-29 21:00:58 +0000 UTCI'd love to hear an interview with Daniel Trachsel. If we are talking about people living in Switzerland, maybe Michael Schlichting who worked with Leuner on LE-25 in psychotherapy could also be interesting.
p4nix
2023-12-29 20:32:55 +0000 UTCHi Xavier - I think so, why not? I'd imagine as more therapists use ketamine there'll be more reports of this, but there's already literature on using ondansetron for nausea during ketamine anesthesia, for example: https://www.sciencedirect.com/science/article/abs/pii/S0735675719305947. The results aren't 100% by any means, but it seems to be of some effect.
Steven
2023-12-29 19:34:38 +0000 UTCI feel dumb. Recently had my first big trip and elected not to take ondansetron because some person online said it might interfere with the experience. My trip sitter caught most of the barf in my designated barf pot, but was still left with a mess to clean up off the floor, while I just laid there, helpless and embarrassed in front of this cool guy I really liked and respected. Even after the stomach issues passed, I was still wracked and yelling "AUGH! AUGH!" because the nausea had somehow transcended my stomach, and yelling my head off seemed to be the only way to expel it. I thought, "what if the entire hours-long trip is like this?!" And then I thought, "well, sometimes things just have to suck for awhile." I realized most of my day-to-day mental energy was spent trying to avoid discomfort. Like, all I used to think about was a decision tree with bad outcomes and I would spend most of my time devising ways to avoid those bad outcomes. Basically, I had anxiety. But sitting through that torturous, bone-deep, full-body nausea just had me thinking: "Things have to suck sometimes. It's ok. Things have to suck sometimes. It's ok..." I took that to heart, and I just don't have anxiety anymore. But I'll take ondansetron next time.
nobody
2023-12-29 16:56:00 +0000 UTCYou might be able to access journals and databases if you live near a university where there is a public library.
Rado
2023-12-29 16:31:55 +0000 UTCIf it's a serious question, in vitro refers to biological studies performed outside of a living organism. Usually this means in a lab. It literally means "in glass", as in a test tube, flask, petrie dish, etc., as opposed to "in vivo" (in a living organism) or "in silico" (a computer simulation).
Brian
2023-12-29 15:28:59 +0000 UTCId love for you to interview Borax! Ive had a few interactions with him in reddit DMs and he's been super helpful, well read and humble. Hes honestly someone whos gonna go down in 2010-drug history books wether he wants to or not.
Helmer
2023-12-29 15:24:00 +0000 UTCIs Ondansetron any effective against dissociative-induced nausea? I’ve found it almost impossible to get rid of
Xavier
2023-12-29 11:00:13 +0000 UTCIn Vitro? I've only heard In Utero. Are you telling me Nirvana made another album?
Jacub White
2023-12-29 10:48:42 +0000 UTCMeherk h .,
Aaron Ochoa
2023-12-29 10:28:34 +0000 UTCPublic comments were instrumental in keeping kratom unscheduled. More than 30,000 comments, many fron licensed medical professionals, completely surprised DEA and forced them to back down. They were trying to push it through under emergency scheduling and failed to meet most of the criteria to do so. Looks like they learned from that and have swung to blaming international treaty with WHO/UN instead butwhy?
TODOOLOO
2023-12-29 10:18:05 +0000 UTCI tried to read the comments posted to the federal register already, and found the site almost unusable. Tried both Safari on an iPad and Brave on an Android... Not super strict security but no 3rd party cookies...which no federal agency should be using! Just another roadblock to democracy i guess.... I'll try posting on a computer rather than a mobile device...
TODOOLOO
2023-12-29 10:03:28 +0000 UTCThanks, Hamilton!
Leigh Bergin
2023-12-29 09:18:29 +0000 UTCThank you for answering my question! It’s quite odd to me that nobody has developed cultivars of most of the psychoactive plants besides cannabis. The only hypothesis I have is that it takes a long time to breed these plants and requires a lot of land to grow your trial fields which is difficult for most people. Psychoactive plants like coca and khat are woody perennial plants with long generation times in breeding programs, as well as being highly heterozygous outcrossers that don’t produce true to type seed and would require clonal propagation by cuttings/grafting. My guess is developing an exceptional cultivar with plants like these would take probably 10-20 years. I work in breeding/genetics research of woody perennial crops so if anyone is looking to try breeding psychoactive plants I’d love to help.
Jahshj
2023-12-29 08:37:13 +0000 UTCDOx? How bored are these assholes? (Rhetorical question, not as bored as they should be, out of a job.)
CSN
2023-12-29 08:33:59 +0000 UTC
